Assay Detail
Binding
CHEMBL839696
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory constant was determined against 5-hydroxytryptamine 1A receptor using 1.2 nM [3H]8-OH-DPAT
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 7.16 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL537403 | — | — | 1 | 9.22 |
| CHEMBL178650 | — | — | 1 | 7.94 |
| CHEMBL178700 | — | — | 1 | 7.75 |
| CHEMBL179648 | — | — | 1 | 7.68 |
| CHEMBL178680 | — | — | 1 | 7.27 |
| CHEMBL179371 | — | — | 1 | 7.24 |
| CHEMBL359663 | — | — | 1 | 7.16 |
| CHEMBL426958 | — | — | 1 | 6.92 |
| CHEMBL180327 | — | — | 1 | 6.76 |
| CHEMBL369091 | — | — | 1 | 6.73 |
| CHEMBL179373 | — | — | 1 | 6.65 |
| CHEMBL178519 | — | — | 1 | 6.58 |
| CHEMBL434905 | — | — | 1 | 6.58 |
| CHEMBL179397 | — | — | 1 | 6.53 |
| CHEMBL425867 | — | — | 1 | 6.35 |
| CHEMBL180180 | — | — | 1 | - |
| CHEMBL369133 | — | — | 1 | - |
| CHEMBL179808 | — | — | 1 | - |
| CHEMBL179145 | — | — | 1 | - |
| CHEMBL276784 | — | — | 1 | - |
| CHEMBL179651 | — | — | 1 | - |
| CHEMBL178988 | — | — | 1 | - |
| CHEMBL179530 | — | — | 1 | - |
| CHEMBL179062 | — | — | 1 | - |
| CHEMBL360351 | — | — | 1 | - |
| CHEMBL362699 | — | — | 1 | - |
| CHEMBL178924 | — | — | 1 | - |
| CHEMBL179697 | — | — | 1 | - |
| CHEMBL180119 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL537403 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL178650 | — | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL178700 | — | Ki | = | 17.6 | nM | 7.75 |
| CHEMBL179648 | — | Ki | = | 20.7 | nM | 7.68 |
| CHEMBL178680 | — | Ki | = | 54.2 | nM | 7.27 |
| CHEMBL179371 | — | Ki | = | 57.2 | nM | 7.24 |
| CHEMBL359663 | — | Ki | = | 69.4 | nM | 7.16 |
| CHEMBL426958 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL180327 | — | Ki | = | 172.0 | nM | 6.76 |
| CHEMBL369091 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL179373 | — | Ki | = | 226.0 | nM | 6.65 |
| CHEMBL178519 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL434905 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL179397 | — | Ki | = | 297.0 | nM | 6.53 |
| CHEMBL425867 | — | Ki | = | 445.0 | nM | 6.35 |
| CHEMBL180180 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL369133 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL179808 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL179145 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL276784 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL179651 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL178988 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL179530 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL179062 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL360351 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL362699 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL178924 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL179697 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL180119 | — | Ki | > | 1000.0 | nM | - |