Assay Detail
Binding
CHEMBL839701
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Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel 3-aminochromans as potential pharmacological tools for the serotonin 5-HT(7) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.77 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95104 | — | — | 1 | 8.70 |
| CHEMBL2112053 | — | — | 1 | 8.28 |
| CHEMBL182792 | — | — | 1 | 8.19 |
| CHEMBL367584 | — | — | 1 | 7.87 |
| CHEMBL183676 | — | — | 1 | 7.12 |
| CHEMBL427326 | — | — | 1 | 6.43 |
| CHEMBL180644 | — | — | 1 | - |
| CHEMBL183677 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95104 | — | Ki | = | 1.99 | nM | 8.70 |
| CHEMBL2112053 | — | Ki | = | 5.29 | nM | 8.28 |
| CHEMBL182792 | — | Ki | = | 6.44 | nM | 8.19 |
| CHEMBL367584 | — | Ki | = | 13.4 | nM | 7.87 |
| CHEMBL183676 | — | Ki | = | 75.9 | nM | 7.12 |
| CHEMBL427326 | — | Ki | = | 367.0 | nM | 6.43 |
| CHEMBL180644 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL183677 | — | Ki | > | 1000.0 | nM | - |