Assay Detail
Binding
CHEMBL839715
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Binding affinity for melanocortin-3 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A potent and selective nonpeptide antagonist of the melanocortin-4 receptor induces food intake in satiated mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.12 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL195308 | — | — | 1 | 6.41 |
| CHEMBL363190 | — | — | 1 | 6.35 |
| CHEMBL194987 | — | — | 1 | 6.25 |
| CHEMBL195071 | — | — | 1 | 6.24 |
| CHEMBL194990 | — | — | 1 | 6.24 |
| CHEMBL365597 | — | — | 1 | 6.19 |
| CHEMBL195110 | — | — | 1 | 6.17 |
| CHEMBL436122 | — | — | 1 | 6.10 |
| CHEMBL363576 | — | — | 1 | 6.10 |
| CHEMBL194393 | — | — | 1 | 6.10 |
| CHEMBL373099 | — | — | 1 | 6.09 |
| CHEMBL192090 | — | — | 1 | 6.08 |
| CHEMBL191701 | — | — | 1 | 6.07 |
| CHEMBL364463 | — | — | 1 | 6.02 |
| CHEMBL191857 | — | — | 1 | 6.00 |
| CHEMBL192464 | — | — | 1 | 5.89 |
| CHEMBL363641 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL195308 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL363190 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL194987 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL195071 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL194990 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL365597 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL195110 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL436122 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL363576 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL194393 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL373099 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL192090 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL191701 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL364463 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL191857 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL192464 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL363641 | — | Ki | = | 1600.0 | nM | 5.80 |