Assay Detail
Binding
CHEMBL839716
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Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]NDP-MSH as radioligand
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A potent and selective nonpeptide antagonist of the melanocortin-4 receptor induces food intake in satiated mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 7.85 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL194990 | — | — | 1 | 8.89 |
| CHEMBL363190 | — | — | 1 | 8.85 |
| CHEMBL195110 | — | — | 1 | 8.82 |
| CHEMBL363576 | — | — | 1 | 8.77 |
| CHEMBL365597 | — | — | 1 | 8.74 |
| CHEMBL194987 | — | — | 1 | 8.70 |
| CHEMBL364463 | — | — | 1 | 8.70 |
| CHEMBL191701 | — | — | 1 | 8.68 |
| CHEMBL195071 | — | — | 1 | 8.62 |
| CHEMBL191857 | — | — | 1 | 8.62 |
| CHEMBL192090 | — | — | 1 | 8.55 |
| CHEMBL195308 | — | — | 1 | 8.54 |
| CHEMBL363641 | — | — | 1 | 8.51 |
| CHEMBL436122 | — | — | 1 | 8.49 |
| CHEMBL192464 | — | — | 1 | 8.35 |
| CHEMBL194393 | — | — | 1 | 8.34 |
| CHEMBL373099 | — | — | 1 | 8.30 |
| CHEMBL195734 | — | — | 1 | 8.30 |
| CHEMBL362985 | — | — | 1 | 8.10 |
| CHEMBL195414 | — | — | 1 | 7.85 |
| CHEMBL186074 | — | — | 1 | 7.82 |
| CHEMBL192153 | — | — | 1 | 7.80 |
| CHEMBL191831 | — | — | 1 | 7.75 |
| CHEMBL191645 | — | — | 1 | 7.75 |
| CHEMBL186083 | — | — | 1 | 7.68 |
| CHEMBL364913 | — | — | 1 | 7.64 |
| CHEMBL193061 | — | — | 1 | 7.64 |
| CHEMBL435933 | — | — | 1 | 7.51 |
| CHEMBL365940 | — | — | 1 | 7.03 |
| CHEMBL40711 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL194990 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL363190 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL195110 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL363576 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL365597 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL194987 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL364463 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL191701 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL195071 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL191857 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL192090 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL195308 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL363641 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL436122 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL192464 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL194393 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL373099 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL195734 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL362985 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL195414 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL186074 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL192153 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL191831 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL191645 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL186083 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL364913 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL193061 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL435933 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL365940 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL40711 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL366171 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL363561 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL193786 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL195172 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL370926 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL194819 | — | Ki | > | 10000.0 | nM | - |