Assay Detail
Binding
CHEMBL839747
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Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of the first potent, selective 5-hydroxytryptamine1D receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.69 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183460 | — | — | 1 | 8.00 |
| CHEMBL190298 | — | — | 1 | 7.20 |
| CHEMBL191605 | — | — | 1 | 7.10 |
| CHEMBL192176 | — | — | 1 | 7.00 |
| CHEMBL2113061 | — | — | 1 | 6.80 |
| CHEMBL364495 | — | — | 1 | 6.70 |
| CHEMBL425190 | — | — | 1 | 6.70 |
| CHEMBL191921 | — | — | 1 | 6.60 |
| CHEMBL191895 | — | — | 1 | 6.60 |
| CHEMBL192536 | — | — | 1 | 6.60 |
| CHEMBL193268 | — | — | 1 | 6.50 |
| CHEMBL362992 | — | — | 1 | 6.50 |
| CHEMBL365810 | — | — | 1 | 6.40 |
| CHEMBL190190 | — | — | 1 | 6.40 |
| CHEMBL363413 | — | — | 1 | 6.20 |
| CHEMBL191980 | — | — | 1 | 5.70 |
| CHEMBL191619 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183460 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL190298 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL191605 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL192176 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL2113061 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL364495 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL425190 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL191921 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL191895 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL192536 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL193268 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL362992 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL365810 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL190190 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL363413 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL191980 | — | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL191619 | — | Ki | < | 10000.0 | nM | - |