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Compound Detail

CHEMBL191980

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Cc1ccc2c(OCCN3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)cccc2n1

Basic Information

ChEMBL ID CHEMBL191980
Phase Preclinical
Structure Type MOL
InChI Key LBMUXQIIUJNCCP-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

430.4
MW (Da)
5.05
ALogP
4
HBA
0
HBD
28.6
PSA (Ų)
0.55
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H25Cl2N3O
MW 430.38
Aromatic Rings 3
Heavy Atoms 29
NP-Likeness -1.49

Activity Summary

Ki 3 meas. best 6.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Sodium-dependent serotonin transporter
CHEMBL313
Ki 6.3 6.3 501.2 1
5-hydroxytryptamine receptor 1B
CHEMBL1898
Ki 5.7 5.7 1995.3 1
5-hydroxytryptamine receptor 1D
CHEMBL1983
Ki 5.6 5.6 2511.9 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15887956 10.1021/jm049039v 5-hydroxytryptamine receptor 1A 1
15887956 10.1021/jm049039v 5-hydroxytryptamine receptor 1B 1
15887956 10.1021/jm049039v 5-hydroxytryptamine receptor 1D 1
15887956 10.1021/jm049039v Sodium-dependent serotonin transporter 1
15887956 10.1021/jm049039v Serotonin 1 receptors; 5-HT1B & 5-HT1D 1

Data from ChEMBL 36 via Core Engine