Assay Detail
Binding
CHEMBL839753
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]nisoxetine from norepinephrine transporter (NET) of rat cerebral cortex
20
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and monoamine transporter binding properties of 3alpha-(substituted phenyl)nortropane-2beta-carboxylic acid methyl esters. Norepinephrine transporter selective compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.79 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365738 | — | — | 1 | 9.37 |
| CHEMBL371607 | — | — | 1 | 8.69 |
| CHEMBL195738 | — | — | 1 | 8.67 |
| CHEMBL366159 | — | — | 1 | 8.59 |
| CHEMBL81525 | — | — | 2 | 8.51 |
| CHEMBL192924 | — | — | 1 | 8.40 |
| CHEMBL80262 | — | — | 2 | 8.36 |
| CHEMBL80515 | — | — | 2 | 8.23 |
| CHEMBL306208 | — | — | 2 | 7.66 |
| CHEMBL192195 | — | — | 1 | 7.65 |
| CHEMBL82027 | — | — | 2 | 7.44 |
| CHEMBL192035 | — | — | 1 | 7.13 |
| CHEMBL2079586 | — | — | 2 | 6.30 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365738 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL371607 | — | Ki | = | 2.05 | nM | 8.69 |
| CHEMBL195738 | — | Ki | = | 2.12 | nM | 8.67 |
| CHEMBL366159 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL81525 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL81525 | — | Ki | = | 3.28 | nM | 8.48 |
| CHEMBL192924 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL80262 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL80262 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL80515 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL80515 | — | Ki | = | 11.3 | nM | 7.95 |
| CHEMBL306208 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL192195 | — | Ki | = | 22.4 | nM | 7.65 |
| CHEMBL306208 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL82027 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL192035 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL82027 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL2079586 | — | Ki | = | 503.0 | nM | 6.30 |
| CHEMBL2079586 | — | Ki | = | 741.0 | nM | 6.13 |
| CHEMBL370805 | COCAINE | Ki | = | 1900.0 | nM | 5.72 |