Assay Detail
Functional
CHEMBL839763
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Agonist activity against rat Opioid receptor mu 1 expressed in C6 cells in [35S]-GTP-gamma S binding assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | C6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Major effect of pyrrolic N-benzylation in norbinaltorphimine, the selective kappa-opioid receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.29 | 6.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2113078 | — | — | 1 | 6.73 |
| CHEMBL2113073 | — | — | 1 | 6.28 |
| CHEMBL606959 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2113078 | — | EC50 | = | 187.0 | nM | 6.73 |
| CHEMBL2113073 | — | EC50 | = | 526.0 | nM | 6.28 |
| CHEMBL606959 | — | EC50 | = | 1388.0 | nM | 5.86 |