Assay Detail
Binding
CHEMBL839921
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In vitro inhibitory activity against tryptase
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.88 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191546 | — | — | 1 | 7.50 |
| CHEMBL365527 | — | — | 1 | 7.39 |
| CHEMBL370284 | — | — | 1 | 7.39 |
| CHEMBL192963 | — | — | 1 | 7.31 |
| CHEMBL193514 | — | — | 1 | 7.24 |
| CHEMBL189101 | — | — | 1 | 7.21 |
| CHEMBL370463 | — | — | 1 | 7.17 |
| CHEMBL365148 | — | — | 1 | 7.00 |
| CHEMBL365189 | — | — | 1 | 6.94 |
| CHEMBL372028 | — | — | 1 | 6.91 |
| CHEMBL364661 | — | — | 1 | 6.90 |
| CHEMBL189531 | — | — | 1 | 6.89 |
| CHEMBL99951 | — | — | 1 | 6.85 |
| CHEMBL190103 | — | — | 1 | 6.85 |
| CHEMBL191007 | — | — | 1 | 6.81 |
| CHEMBL435694 | — | — | 1 | 6.79 |
| CHEMBL361040 | — | — | 1 | 6.73 |
| CHEMBL372912 | — | — | 1 | 6.71 |
| CHEMBL190000 | — | — | 1 | 6.62 |
| CHEMBL192214 | — | — | 1 | 6.61 |
| CHEMBL436537 | — | — | 1 | 6.54 |
| CHEMBL190135 | — | — | 1 | 6.51 |
| CHEMBL189983 | — | — | 1 | 6.43 |
| CHEMBL189372 | — | — | 1 | 6.43 |
| CHEMBL191731 | — | — | 1 | 6.30 |
| CHEMBL188104 | — | — | 1 | - |
| CHEMBL191072 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191546 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL365527 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL370284 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL192963 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL193514 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL189101 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL370463 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL365148 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL365189 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL372028 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL364661 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL189531 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL99951 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL190103 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL191007 | — | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL435694 | — | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL361040 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL372912 | — | Ki | = | 197.0 | nM | 6.71 |
| CHEMBL190000 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL192214 | — | Ki | = | 246.0 | nM | 6.61 |
| CHEMBL436537 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL190135 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL189983 | — | Ki | = | 368.0 | nM | 6.43 |
| CHEMBL189372 | — | Ki | = | 373.0 | nM | 6.43 |
| CHEMBL191731 | — | Ki | = | 497.0 | nM | 6.30 |
| CHEMBL188104 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL191072 | — | Ki | > | 20000.0 | nM | - |