Assay Detail
Binding
CHEMBL840047
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Binding affinity against Prostaglandin E receptor in presence of 2% human serum albumin
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Prostaglandin E2 receptor EP1 subtype (CHEMBL1811) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2,3-Diarylthiophenes as selective EP1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.43 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185346 | — | — | 1 | 8.30 |
| CHEMBL180046 | — | — | 1 | 8.30 |
| CHEMBL182368 | — | — | 1 | 8.22 |
| CHEMBL360592 | — | — | 1 | 7.77 |
| CHEMBL2113029 | — | — | 1 | 7.75 |
| CHEMBL362543 | — | — | 1 | 7.16 |
| CHEMBL182662 | — | — | 1 | 7.14 |
| CHEMBL184947 | — | — | 1 | 7.05 |
| CHEMBL182623 | — | — | 1 | 6.80 |
| CHEMBL184779 | — | — | 1 | 6.66 |
| CHEMBL362851 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185346 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL180046 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL182368 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL360592 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL2113029 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL362543 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL182662 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL184947 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL182623 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL184779 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL362851 | — | Ki | = | 280.0 | nM | 6.55 |