Assay Detail
Binding
CHEMBL840063
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Binding inhibition constant was determined by inhibition of [125I]-iodocyanopindolol binding to Beta-1 adrenergic receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tryptamine-based human beta3-adrenergic receptor agonists. Part 2: SAR of the methylene derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.09 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442225 | — | — | 1 | 7.47 |
| CHEMBL184407 | — | — | 1 | 7.18 |
| CHEMBL186247 | — | — | 1 | 7.05 |
| CHEMBL188622 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442225 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL184407 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL186247 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL188622 | — | Ki | = | 230.0 | nM | 6.64 |