Assay Detail
Binding
CHEMBL840087
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In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The impact of spacer structure on 5-HT7 and 5-HT1A receptor affinity in the group of long-chain arylpiperazine ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.44 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186334 | — | — | 1 | 7.44 |
| CHEMBL365412 | — | — | 1 | 7.20 |
| CHEMBL8618 | NAN-190 | — | 1 | 7.06 |
| CHEMBL279841 | — | — | 1 | 7.05 |
| CHEMBL365201 | — | — | 1 | 6.45 |
| CHEMBL185988 | — | — | 1 | 6.43 |
| CHEMBL186734 | — | — | 1 | 6.10 |
| CHEMBL185936 | — | — | 1 | 6.04 |
| CHEMBL441313 | — | — | 1 | 5.69 |
| CHEMBL187270 | — | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186334 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL365412 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL8618 | NAN-190 | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL279841 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL365201 | — | Ki | = | 353.0 | nM | 6.45 |
| CHEMBL185988 | — | Ki | = | 367.0 | nM | 6.43 |
| CHEMBL186734 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL185936 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL441313 | — | Ki | = | 2045.0 | nM | 5.69 |
| CHEMBL187270 | — | Ki | = | 11500.0 | nM | 4.94 |