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Assay Detail

CHEMBL840099

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Binding
Inhibitory activity against carbonic anhydrase
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Topological modeling of lipophilicity, diuretic activity, and carbonic inhibition activity of benzene sulfonamides: a molecular connectivity approach.
Jaiswal M, Khadikar PV, Supuran CT.
Bioorg Med Chem Lett (2004) 14 : 5661 -5666
PubMed 15482943 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 19 5.64 6.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL181397 1 6.85
CHEMBL51663 1 6.76
CHEMBL366729 1 6.39
CHEMBL282157 1 6.04
CHEMBL172294 1 5.95
CHEMBL178209 1 5.95
CHEMBL178852 1 5.92
CHEMBL367035 1 5.88
CHEMBL804 P-CHLOROBENZENESULFONAMIDE 1 5.72
CHEMBL369271 1 5.63
CHEMBL367983 1 5.52
CHEMBL574 P-TOLUENESULFONAMIDE 3.0 1 5.42
CHEMBL176402 1 5.34
CHEMBL173363 1 5.30
CHEMBL27601 BENZENESULFONAMIDE 1 5.21
CHEMBL361396 1 5.07
CHEMBL174847 1 4.87
CHEMBL176892 1 4.79
CHEMBL21 SULFANILAMIDE 4.0 1 4.63

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL181397 Ki = 141.25 nM 6.85
CHEMBL51663 Ki = 173.78 nM 6.76
CHEMBL366729 Ki = 407.38 nM 6.39
CHEMBL282157 Ki = 912.01 nM 6.04
CHEMBL172294 Ki = 1122.02 nM 5.95
CHEMBL178209 Ki = 1122.02 nM 5.95
CHEMBL178852 Ki = 1202.26 nM 5.92
CHEMBL367035 Ki = 1318.26 nM 5.88
CHEMBL804 P-CHLOROBENZENESULFONAMIDE Ki = 1905.46 nM 5.72
CHEMBL369271 Ki = 2344.23 nM 5.63
CHEMBL367983 Ki = 3019.95 nM 5.52
CHEMBL574 P-TOLUENESULFONAMIDE Ki = 3801.89 nM 5.42
CHEMBL176402 Ki = 4570.88 nM 5.34
CHEMBL173363 Ki = 5011.87 nM 5.30
CHEMBL27601 BENZENESULFONAMIDE Ki = 6165.95 nM 5.21
CHEMBL361396 Ki = 8511.38 nM 5.07
CHEMBL174847 Ki = 13489.63 nM 4.87
CHEMBL176892 Ki = 16218.1 nM 4.79
CHEMBL21 SULFANILAMIDE Ki = 23442.29 nM 4.63