Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL367983

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
NS(=O)(=O)c1ccccc1Cl

Basic Information

ChEMBL ID CHEMBL367983
Phase Preclinical
Structure Type MOL
InChI Key JCCBZCMSYUSCFM-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

191.6
MW (Da)
0.99
ALogP
2
HBA
1
HBD
60.2
PSA (Ų)
0.72
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C6H6ClNO2S
MW 191.64
Aromatic Rings 1
Heavy Atoms 11
NP-Likeness -2.03

Activity Summary

Ki 2 meas. best 5.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Ki 5.52 5.52 3019.9 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked Ki = 3019.95 nM 5.52 Inhibitory activity against carbonic anhydrase 15482943

Literature References

PubMed DOI Target Context # Activities
2709382 10.1021/jm00125a005 Unchecked 1
15686889 10.1016/j.bmcl.2004.12.057 Unchecked 1
15686889 10.1016/j.bmcl.2004.12.057 ADMET 1
15686889 10.1016/j.bmcl.2004.12.057 No relevant target 1
15482943 10.1016/j.bmcl.2004.08.051 ADMET 1
15482943 10.1016/j.bmcl.2004.08.051 Unchecked 1
15482943 10.1016/j.bmcl.2004.08.051 No relevant target 1
28129991 10.1016/j.bmc.2017.01.012 PI3-kinase p110-alpha/p85-alpha 1
28129991 10.1016/j.bmc.2017.01.012 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
38318365 10.1016/j.isci.2024.108907 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1

Data from ChEMBL 36 via Core Engine