Assay Detail
Binding
CHEMBL840152
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Binding affinity against human cloned 5-hydroxytryptamine 1A receptor stably expressed in CHO cells using [3H]5-HT
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.45 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL181066 | — | — | 1 | 7.01 |
| CHEMBL178870 | — | — | 1 | 6.94 |
| CHEMBL180606 | — | — | 1 | 6.06 |
| CHEMBL444015 | — | — | 1 | 5.78 |
| CHEMBL362487 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL181066 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL178870 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL180606 | — | Ki | = | 875.0 | nM | 6.06 |
| CHEMBL444015 | — | Ki | = | 1670.0 | nM | 5.78 |
| CHEMBL362487 | — | Ki | > | 2000.0 | nM | - |