Assay Detail
Binding
CHEMBL840199
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Binding affinity for human estrogen receptor alpha
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of novel quinoline-based estrogen receptor ligands using peptide interaction profiling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.55 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 8.70 |
| CHEMBL195515 | — | — | 1 | 8.60 |
| CHEMBL2137046 | — | — | 1 | 8.60 |
| CHEMBL195080 | — | — | 1 | 8.10 |
| CHEMBL370750 | — | — | 1 | 8.00 |
| CHEMBL194774 | — | — | 1 | 8.00 |
| CHEMBL363630 | — | — | 1 | 7.80 |
| CHEMBL193865 | — | — | 1 | 7.60 |
| CHEMBL192025 | — | — | 1 | 7.00 |
| CHEMBL370492 | — | — | 1 | 6.90 |
| CHEMBL193730 | — | — | 1 | 5.80 |
| CHEMBL194600 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL195515 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL2137046 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL195080 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL370750 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL194774 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL363630 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL193865 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL192025 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL370492 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL193730 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL194600 | — | Ki | = | 3162.28 | nM | 5.50 |