Assay Detail
Binding
CHEMBL840213
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Inhibitory constant value against the 5-hydroxytryptamine 1A receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1,2,4-Benzothiadiazine derivatives as alpha1 and 5-HT1A receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.80 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13647 | BMY-7378 | — | 1 | 8.90 |
| CHEMBL359915 | — | — | 1 | 8.04 |
| CHEMBL180874 | — | — | 1 | 7.78 |
| CHEMBL181373 | — | — | 1 | 7.33 |
| CHEMBL178113 | — | — | 1 | 6.97 |
| CHEMBL180831 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13647 | BMY-7378 | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL359915 | — | Ki | = | 9.12 | nM | 8.04 |
| CHEMBL180874 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL181373 | — | Ki | = | 46.77 | nM | 7.33 |
| CHEMBL178113 | — | Ki | = | 107.15 | nM | 6.97 |
| CHEMBL180831 | — | Ki | < | 100.0 | nM | - |