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Assay Detail

CHEMBL840221

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Binding
Binding affinity against Opioid receptor kappa 1 from guinea pig brain membranes using [3H]U-69593
ChEMBL ↗
85
Total Activities
85
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Kappa-type opioid receptor (CHEMBL3952) ↗
Type SINGLE PROTEIN
Organism Cavia porcellus

Publication

3D-QSAR comparative molecular field analysis on opioid receptor antagonists: pooling data from different studies.
Peng Y, Keenan SM, Zhang Q, Kholodovych V, Welsh WJ.
J Med Chem (2005) 48 : 1620 -1629
PubMed 15743203 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 85 6.60 8.23

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL370966 — — 1 8.23
CHEMBL364247 — — 1 8.22
CHEMBL195770 — — 1 8.20
CHEMBL195316 — — 1 8.15
CHEMBL370735 — — 1 8.13
CHEMBL195784 — — 1 8.06
CHEMBL363348 — — 1 7.96
CHEMBL195562 — — 1 7.92
CHEMBL195040 — — 1 7.88
CHEMBL192443 — — 1 7.75
CHEMBL370544 — — 1 7.74
CHEMBL195684 — — 1 7.70
CHEMBL610880 — — 1 7.70
CHEMBL371845 — — 1 7.64
CHEMBL425735 — — 1 7.63
CHEMBL363601 — — 1 7.60
CHEMBL567175 NALTRINDOLE — 1 7.57
CHEMBL611398 — — 1 7.47
CHEMBL611393 — — 1 7.44
CHEMBL316930 — — 1 7.42
CHEMBL372439 — — 1 7.25
CHEMBL610798 — — 1 7.23
CHEMBL611399 — — 1 7.12
CHEMBL364937 — — 1 7.12
CHEMBL265033 — — 1 7.11
CHEMBL611132 — — 1 7.09
CHEMBL195756 — — 1 7.09
CHEMBL425728 — — 1 7.04
CHEMBL322796 CYPRODIME — 1 6.96
CHEMBL607118 — — 1 6.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL370966 — Ki = 5.888 nM 8.23
CHEMBL364247 — Ki = 6.026 nM 8.22
CHEMBL195770 — Ki = 6.31 nM 8.20
CHEMBL195316 — Ki = 7.079 nM 8.15
CHEMBL370735 — Ki = 7.413 nM 8.13
CHEMBL195784 — Ki = 8.71 nM 8.06
CHEMBL363348 — Ki = 10.96 nM 7.96
CHEMBL195562 — Ki = 12.02 nM 7.92
CHEMBL195040 — Ki = 13.18 nM 7.88
CHEMBL192443 — Ki = 17.78 nM 7.75
CHEMBL370544 — Ki = 18.2 nM 7.74
CHEMBL195684 — Ki = 19.95 nM 7.70
CHEMBL610880 — Ki = 19.95 nM 7.70
CHEMBL371845 — Ki = 22.91 nM 7.64
CHEMBL425735 — Ki = 23.44 nM 7.63
CHEMBL363601 — Ki = 25.12 nM 7.60
CHEMBL567175 NALTRINDOLE Ki = 26.92 nM 7.57
CHEMBL611398 — Ki = 33.88 nM 7.47
CHEMBL611393 — Ki = 36.31 nM 7.44
CHEMBL316930 — Ki = 38.02 nM 7.42
CHEMBL372439 — Ki = 56.23 nM 7.25
CHEMBL610798 — Ki = 58.88 nM 7.23
CHEMBL611399 — Ki = 75.86 nM 7.12
CHEMBL364937 — Ki = 75.86 nM 7.12
CHEMBL265033 — Ki = 77.62 nM 7.11
CHEMBL611132 — Ki = 81.28 nM 7.09
CHEMBL195756 — Ki = 81.28 nM 7.09
CHEMBL425728 — Ki = 91.2 nM 7.04
CHEMBL322796 CYPRODIME Ki = 109.65 nM 6.96
CHEMBL607118 — Ki = 120.23 nM 6.92
CHEMBL195477 — Ki = 123.03 nM 6.91
CHEMBL606795 — Ki = 125.89 nM 6.90
CHEMBL190978 — Ki = 151.36 nM 6.82
CHEMBL370759 — Ki = 208.93 nM 6.68
CHEMBL2112570 — Ki = 213.8 nM 6.67
CHEMBL611396 — Ki = 234.42 nM 6.63
CHEMBL610620 — Ki = 257.04 nM 6.59
CHEMBL611144 — Ki = 263.03 nM 6.58
CHEMBL194021 — Ki = 263.03 nM 6.58
CHEMBL2112573 — Ki = 269.15 nM 6.57
CHEMBL195879 — Ki = 275.42 nM 6.56
CHEMBL608246 — Ki = 288.4 nM 6.54
CHEMBL317536 — Ki = 302.0 nM 6.52
CHEMBL611131 — Ki = 309.03 nM 6.51
CHEMBL610878 — Ki = 354.81 nM 6.45
CHEMBL195411 — Ki = 363.08 nM 6.44
CHEMBL427546 — Ki = 363.08 nM 6.44
CHEMBL606740 — Ki = 380.19 nM 6.42
CHEMBL363777 — Ki = 407.38 nM 6.39
CHEMBL193586 — Ki = 436.52 nM 6.36