Assay Detail
Binding
CHEMBL840258
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Binding affinity against metabotropic glutamate receptor 2
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 6.34 | 6.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179939 | — | — | 1 | 6.91 |
| CHEMBL179839 | — | — | 1 | 6.78 |
| CHEMBL181364 | — | — | 1 | 6.73 |
| CHEMBL182946 | — | — | 1 | 6.71 |
| CHEMBL180186 | — | — | 1 | 6.65 |
| CHEMBL361837 | — | — | 1 | 6.65 |
| CHEMBL183911 | — | — | 1 | 6.57 |
| CHEMBL367823 | — | — | 1 | 6.56 |
| CHEMBL183541 | — | — | 1 | 6.55 |
| CHEMBL180871 | — | — | 1 | 6.54 |
| CHEMBL181869 | — | — | 1 | 6.43 |
| CHEMBL180455 | — | — | 1 | 6.36 |
| CHEMBL369526 | — | — | 1 | 6.29 |
| CHEMBL179876 | — | — | 1 | 6.25 |
| CHEMBL183234 | — | — | 1 | 6.23 |
| CHEMBL359909 | — | — | 1 | 6.22 |
| CHEMBL361358 | — | — | 1 | 6.22 |
| CHEMBL361633 | — | — | 1 | 6.20 |
| CHEMBL183286 | — | — | 1 | 6.12 |
| CHEMBL180488 | — | — | 1 | 6.11 |
| CHEMBL179171 | — | — | 1 | 6.08 |
| CHEMBL154542 | — | — | 1 | 6.05 |
| CHEMBL361570 | — | — | 1 | 5.96 |
| CHEMBL178823 | — | — | 1 | 5.94 |
| CHEMBL182138 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179939 | — | EC50 | = | 122.0 | nM | 6.91 |
| CHEMBL179839 | — | EC50 | = | 165.0 | nM | 6.78 |
| CHEMBL181364 | — | EC50 | = | 186.0 | nM | 6.73 |
| CHEMBL182946 | — | EC50 | = | 195.0 | nM | 6.71 |
| CHEMBL180186 | — | EC50 | = | 223.0 | nM | 6.65 |
| CHEMBL361837 | — | EC50 | = | 225.0 | nM | 6.65 |
| CHEMBL183911 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL367823 | — | EC50 | = | 276.0 | nM | 6.56 |
| CHEMBL183541 | — | EC50 | = | 282.0 | nM | 6.55 |
| CHEMBL180871 | — | EC50 | = | 291.0 | nM | 6.54 |
| CHEMBL181869 | — | EC50 | = | 371.0 | nM | 6.43 |
| CHEMBL180455 | — | EC50 | = | 442.0 | nM | 6.36 |
| CHEMBL369526 | — | EC50 | = | 515.0 | nM | 6.29 |
| CHEMBL179876 | — | EC50 | = | 562.0 | nM | 6.25 |
| CHEMBL183234 | — | EC50 | = | 589.0 | nM | 6.23 |
| CHEMBL359909 | — | EC50 | = | 596.0 | nM | 6.22 |
| CHEMBL361358 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL361633 | — | EC50 | = | 629.0 | nM | 6.20 |
| CHEMBL183286 | — | EC50 | = | 761.0 | nM | 6.12 |
| CHEMBL180488 | — | EC50 | = | 782.0 | nM | 6.11 |
| CHEMBL179171 | — | EC50 | = | 839.0 | nM | 6.08 |
| CHEMBL154542 | — | EC50 | = | 892.0 | nM | 6.05 |
| CHEMBL361570 | — | EC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL178823 | — | EC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL182138 | — | EC50 | = | 5000.0 | nM | 5.30 |