Compound Detail
CHEMBL182138
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Basic Information
| ChEMBL ID | CHEMBL182138 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UOJKSVVDYDTODM-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
409.3
MW (Da)
4.45
ALogP
5
HBA
1
HBD
80.8
PSA (Ų)
0.71
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 CHEMBL5137 | EC50 | 5.3 | 5.3 | 5000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 | EC50 | = | 5000.0 | nM | 5.3 | Binding affinity against metabotropic glutamate receptor 2 | 15745798 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15745798 | 10.1016/j.bmcl.2005.01.077 | Metabotropic glutamate receptor 2 | 1 |
| 15745798 | 10.1016/j.bmcl.2005.01.077 | Cell line | 1 |
Data from ChEMBL 36 via Core Engine