Assay Detail
Functional
CHEMBL840569
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity in T79-A3 (NR-positive) cell lines
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Modulator of drug activity A (CHEMBL5502) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli O157:H7 |
Publication
Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.55 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23065 | — | — | 1 | 7.00 |
| CHEMBL22592 | — | — | 1 | 6.72 |
| CHEMBL23216 | — | — | 1 | 6.64 |
| CHEMBL23612 | — | — | 1 | 6.60 |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | 6.05 |
| CHEMBL23355 | — | — | 1 | 5.72 |
| CHEMBL23558 | — | — | 1 | 5.47 |
| CHEMBL23938 | — | — | 1 | 5.40 |
| CHEMBL22728 | — | — | 1 | 5.12 |
| CHEMBL23066 | — | — | 1 | 5.03 |
| CHEMBL282510 | — | — | 1 | 4.89 |
| CHEMBL281812 | — | — | 1 | 4.82 |
| CHEMBL282488 | — | — | 1 | 4.24 |
| CHEMBL281563 | — | — | 1 | 4.05 |
| CHEMBL23441 | — | — | 1 | - |
| CHEMBL22212 | — | — | 1 | - |
| CHEMBL282461 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23065 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL22592 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL23216 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL23612 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL23330 | TRETAZICAR | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL23355 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL23558 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL23938 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL22728 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL23066 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL282510 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL281812 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL282488 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL281563 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL23441 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL22212 | — | IC50 | = | 895000.0 | nM | - |
| CHEMBL282461 | — | IC50 | = | 207000.0 | nM | - |