Assay Detail
Functional
CHEMBL840825
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration to increase glycogen deposition in rat skeletal muscle L6 myoblast cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Glycogen synthase kinase-3 beta (CHEMBL3669) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
N-Phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amines as potent and selective inhibitors of glycogen synthase kinase 3 with good cellular efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 5.72 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361894 | GW806290X | — | 1 | 6.10 |
| CHEMBL188665 | — | — | 1 | 6.00 |
| CHEMBL184510 | — | — | 1 | 6.00 |
| CHEMBL361697 | — | — | 1 | 6.00 |
| CHEMBL360206 | — | — | 1 | 5.92 |
| CHEMBL187081 | PYRAZOLOPYRIDAZINE 1 | — | 1 | 5.89 |
| CHEMBL186054 | PYRAZOLOPYRIDAZINE 2 | — | 1 | 5.82 |
| CHEMBL360408 | — | — | 1 | 5.80 |
| CHEMBL186101 | — | — | 1 | 5.75 |
| CHEMBL263448 | — | — | 1 | 5.68 |
| CHEMBL189343 | — | — | 1 | 5.55 |
| CHEMBL359554 | — | — | 1 | 5.54 |
| CHEMBL364197 | — | — | 1 | 5.47 |
| CHEMBL434158 | — | — | 1 | 5.44 |
| CHEMBL439850 | — | — | 1 | 5.38 |
| CHEMBL182493 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361894 | GW806290X | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL188665 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL184510 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL361697 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL360206 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL187081 | PYRAZOLOPYRIDAZINE 1 | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL186054 | PYRAZOLOPYRIDAZINE 2 | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL360408 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL186101 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL263448 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL189343 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL359554 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL364197 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL434158 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL439850 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL182493 | — | EC50 | = | 6800.0 | nM | 5.17 |