Assay Detail
Binding
CHEMBL841264
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In vitro inhibition of murine Lck kinase.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase LCK (CHEMBL2480) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.70 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131346 | — | — | 1 | 7.16 |
| CHEMBL338159 | — | — | 1 | 6.77 |
| CHEMBL130719 | — | — | 1 | 6.50 |
| CHEMBL128589 | — | — | 1 | 6.14 |
| CHEMBL132399 | — | — | 1 | 4.61 |
| CHEMBL336330 | — | — | 1 | 4.39 |
| CHEMBL128568 | — | — | 1 | 4.34 |
| CHEMBL130943 | — | — | 1 | - |
| CHEMBL130075 | — | — | 1 | - |
| CHEMBL131167 | — | — | 1 | - |
| CHEMBL128795 | — | — | 1 | - |
| CHEMBL128455 | — | — | 1 | - |
| CHEMBL341026 | — | — | 1 | - |
| CHEMBL334341 | — | — | 1 | - |
| CHEMBL424450 | — | — | 1 | - |
| CHEMBL336544 | — | — | 1 | - |
| CHEMBL423516 | — | — | 1 | - |
| CHEMBL338488 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131346 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL338159 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL130719 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL128589 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL132399 | — | IC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL336330 | — | IC50 | = | 40300.0 | nM | 4.39 |
| CHEMBL128568 | — | IC50 | = | 45700.0 | nM | 4.34 |
| CHEMBL130943 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL130075 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL131167 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL128795 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL128455 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL341026 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL334341 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL424450 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL336544 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL423516 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL338488 | — | IC50 | > | 50000.0 | nM | - |