Assay Detail
Binding
CHEMBL841397
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Inhibition of human p56 Lck tyrosine kinase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.38 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340322 | — | — | 1 | 5.85 |
| CHEMBL66109 | — | — | 1 | 5.82 |
| CHEMBL129454 | — | — | 1 | 5.36 |
| CHEMBL307976 | — | — | 1 | 5.30 |
| CHEMBL334333 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340322 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL66109 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL129454 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL307976 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL334333 | — | IC50 | = | 28000.0 | nM | 4.55 |