Compound Detail
CHEMBL307976
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Basic Information
| ChEMBL ID | CHEMBL307976 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NJHVQEJXKUFUMU-UHFFFAOYSA-N |
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
275.4
MW (Da)
3.21
ALogP
4
HBA
2
HBD
68.0
PSA (Ų)
0.88
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 5.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase Lck CHEMBL258 | IC50 | 5.5 | 5.3667 | 3200.0 | 3 |
| Proto-oncogene tyrosine-protein kinase LCK CHEMBL2480 | IC50 | 5.18 | 5.18 | 6600.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase Lck | IC50 | = | 3200.0 | nM | 5.5 | In vitro inhibition of phosphorylation of an exogenous substrate by human p56 Lc... | 12798323 |
| Tyrosine-protein kinase Lck | IC50 | = | 5000.0 | nM | 5.3 | Inhibition of human p56 Lck tyrosine kinase | 14592495 |
| Tyrosine-protein kinase Lck | IC50 | = | 5000.0 | nM | 5.3 | Inhibition of human Lck in presence of ATP | 17154512 |
| Proto-oncogene tyrosine-protein kinase LCK | IC50 | = | 6600.0 | nM | 5.18 | Inhibition of mouse p56 Lck tyrosine kinase | 14592495 |
| Proto-oncogene tyrosine-protein kinase LCK | IC50 | = | 6600.0 | nM | 5.18 | Inhibition of murine Lck in presence of ATP | 17154512 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14592495 | 10.1016/j.bmcl.2003.08.054 | Proto-oncogene tyrosine-protein kinase LCK | 1 |
| 14592495 | 10.1016/j.bmcl.2003.08.054 | Tyrosine-protein kinase Lck | 1 |
| 12798323 | 10.1016/s0960-894x(03)00380-9 | Tyrosine-protein kinase Lck | 1 |
| 17154512 | 10.1021/jm060727j | Proto-oncogene tyrosine-protein kinase LCK | 1 |
| 17154512 | 10.1021/jm060727j | Tyrosine-protein kinase Lck | 1 |
| 17154512 | 10.1021/jm060727j | T-cell | 1 |
Data from ChEMBL 36 via Core Engine