Assay Detail
Functional
CHEMBL841401
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Inhibitory activity against LPS-stimulated IL-1 beta release from human monocytes
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel cytokine release inhibitors. Part III: Truncated analogs of tripterine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.97 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121164 | — | — | 1 | 10.00 |
| CHEMBL121430 | — | — | 1 | 9.72 |
| CHEMBL301982 | CELASTROL | — | 1 | 7.40 |
| CHEMBL292578 | PRISTIMEROL DIACETATE | — | 1 | 7.10 |
| CHEMBL120991 | — | — | 1 | 7.10 |
| CHEMBL332596 | — | — | 1 | 7.00 |
| CHEMBL121213 | — | — | 1 | 6.85 |
| CHEMBL121583 | — | — | 1 | 6.70 |
| CHEMBL331001 | — | — | 1 | 6.70 |
| CHEMBL439971 | — | — | 1 | 6.70 |
| CHEMBL120161 | — | — | 1 | 6.52 |
| CHEMBL330988 | — | — | 1 | 6.16 |
| CHEMBL121184 | — | — | 1 | 6.16 |
| CHEMBL122826 | — | — | 1 | 6.05 |
| CHEMBL331568 | — | — | 1 | 5.66 |
| CHEMBL267202 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121164 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL121430 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL301982 | CELASTROL | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL292578 | PRISTIMEROL DIACETATE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL120991 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL332596 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL121213 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL121583 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL331001 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL439971 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL120161 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL330988 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL121184 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL122826 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL331568 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL267202 | — | IC50 | = | 2400.0 | nM | 5.62 |