Assay Detail
Functional
CHEMBL841403
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Compound was tested for inhibitory effect on LPS-stimulated IL-1 alpha release from human monocytes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel cytokine release inhibitors. Part III: Truncated analogs of tripterine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.91 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301982 | CELASTROL | — | 1 | 7.40 |
| CHEMBL267202 | — | — | 1 | 7.00 |
| CHEMBL121164 | — | — | 1 | 6.89 |
| CHEMBL330988 | — | — | 1 | 6.66 |
| CHEMBL121430 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301982 | CELASTROL | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL267202 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL121164 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL330988 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL121430 | — | IC50 | = | 240.0 | nM | 6.62 |