Assay Detail
Functional
CHEMBL841434
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Inhibition of adp-induced platelet aggregation in human platelet rich plasma.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.15 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL100784 | — | — | 1 | 8.52 |
| CHEMBL88583 | — | — | 1 | 7.70 |
| CHEMBL100676 | — | — | 1 | 7.52 |
| CHEMBL98164 | — | — | 1 | 6.75 |
| CHEMBL99760 | — | — | 1 | 6.40 |
| CHEMBL760 | ANAGRELIDE | 4.0 | 1 | 5.98 |
| CHEMBL100365 | — | — | 1 | - |
| CHEMBL100030 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL100784 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL88583 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL100676 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL98164 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL99760 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL760 | ANAGRELIDE | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL100365 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL100030 | — | EC50 | > | 140000.0 | nM | - |