Assay Detail
Binding
CHEMBL841529
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Inhibitory concentration against recombinant human (neuronal nitric oxide synthase) n-NOS
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.83 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293212 | — | — | 1 | 7.46 |
| CHEMBL545441 | — | — | 1 | 7.38 |
| CHEMBL542132 | — | — | 1 | 7.32 |
| CHEMBL227744 | NITROARGININE | 1.0 | 1 | 7.10 |
| CHEMBL292099 | — | — | 1 | 6.85 |
| CHEMBL544514 | — | — | 1 | 6.85 |
| CHEMBL61969 | — | — | 1 | 6.80 |
| CHEMBL552822 | — | — | 1 | 6.77 |
| CHEMBL538997 | — | — | 1 | 6.77 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 6.05 |
| CHEMBL7890 | L-NAME | 2.0 | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293212 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL545441 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL542132 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL227744 | NITROARGININE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL292099 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL544514 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL61969 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL552822 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL538997 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL256147 | TILARGININE | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL7890 | L-NAME | IC50 | = | 1600.0 | nM | 5.80 |