Assay Detail
Binding
CHEMBL841530
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Compound was evaluated for the binding constant for association with nicotinic acetylcholine receptor (nAChR)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Torpedo californica |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Bis-catechol-substituted redox-reactive analogues of hexamethonium and decamethonium: stimulated affinity-dependent reactivity through iron peroxide catalysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.71 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL136284 | — | — | 1 | 7.75 |
| CHEMBL138569 | — | — | 1 | 6.64 |
| CHEMBL332524 | HEXAMETHONIUM BROMIDE | 2.0 | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL136284 | — | Kd | = | 18.0 | nM | 7.75 |
| CHEMBL138569 | — | Kd | = | 230.0 | nM | 6.64 |
| CHEMBL332524 | HEXAMETHONIUM BROMIDE | Kd | = | 1800.0 | nM | 5.75 |