Assay Detail
Functional
CHEMBL841660
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Inhibition of IL1-beta release stimulated with LPS in human monocytes
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel cytokine release inhibitors. Part IV: analogs of podocarpic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.73 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301982 | CELASTROL | — | 1 | 7.40 |
| CHEMBL292578 | PRISTIMEROL DIACETATE | — | 1 | 7.10 |
| CHEMBL142413 | — | — | 1 | 7.00 |
| CHEMBL344129 | — | — | 1 | 7.00 |
| CHEMBL142965 | — | — | 1 | 7.00 |
| CHEMBL341907 | — | — | 1 | 7.00 |
| CHEMBL142845 | — | — | 1 | 7.00 |
| CHEMBL143595 | — | — | 1 | 7.00 |
| CHEMBL345984 | — | — | 1 | 7.00 |
| CHEMBL342502 | — | — | 1 | 6.96 |
| CHEMBL142267 | — | — | 1 | 6.96 |
| CHEMBL141490 | — | — | 1 | 6.96 |
| CHEMBL357473 | — | — | 1 | 6.96 |
| CHEMBL357472 | — | — | 1 | 6.96 |
| CHEMBL141765 | — | — | 1 | 6.85 |
| CHEMBL357839 | — | — | 1 | 6.82 |
| CHEMBL141822 | — | — | 1 | 6.82 |
| CHEMBL142266 | — | — | 1 | 6.80 |
| CHEMBL343031 | — | — | 1 | 6.80 |
| CHEMBL141445 | — | — | 1 | 6.70 |
| CHEMBL414441 | — | — | 1 | 6.70 |
| CHEMBL142407 | — | — | 1 | 6.58 |
| CHEMBL143315 | — | — | 1 | 6.52 |
| CHEMBL358515 | — | — | 1 | 6.52 |
| CHEMBL143705 | — | — | 1 | 6.40 |
| CHEMBL141325 | — | — | 1 | 6.40 |
| CHEMBL439614 | — | — | 1 | 6.27 |
| CHEMBL143314 | — | — | 1 | 6.10 |
| CHEMBL356100 | — | — | 1 | 6.10 |
| CHEMBL343035 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301982 | CELASTROL | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL292578 | PRISTIMEROL DIACETATE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL142413 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL344129 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL142965 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL341907 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL142845 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL143595 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL345984 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL342502 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL142267 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL141490 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL357473 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL357472 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL141765 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL141822 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL357839 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL142266 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL343031 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL141445 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL414441 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL142407 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL143315 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL358515 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL143705 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL141325 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL439614 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL143314 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL356100 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL343035 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL357826 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL434514 | — | IC50 | > | 3.0 | nM | - |