Assay Detail
Functional
CHEMBL841664
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit production of arachidonic acid from whole blood stimulated with A-23187
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.72 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385730 | — | — | 1 | 6.72 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
| CHEMBL15594 | ARACHIDONIC ACID | -1.0 | 1 | - |
| CHEMBL281211 | ARACHIDONYL TRIFLUOROMETHYLKETONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385730 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL6 | INDOMETHACIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL15594 | ARACHIDONIC ACID | IC50 | > | 10000.0 | nM | - |
| CHEMBL281211 | ARACHIDONYL TRIFLUOROMETHYLKETONE | IC50 | > | 10000.0 | nM | - |