Assay Detail
Functional
CHEMBL841665
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In vitro assay for PGE-2 production as a function of COX-2 inhibition in whole human blood cultured with lipopolysaccharide (LPS)
6
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.44 | 6.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 2 | 6.79 |
| CHEMBL1147 | HYDROXYLATED DERIVATIVE | — | 2 | 6.48 |
| CHEMBL865 | VALDECOXIB | 4.0 | 2 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL118 | CELECOXIB | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL1147 | HYDROXYLATED DERIVATIVE | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL1147 | HYDROXYLATED DERIVATIVE | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL865 | VALDECOXIB | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL865 | VALDECOXIB | IC50 | = | 890.0 | nM | 6.05 |