Assay Detail
Functional
CHEMBL841666
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Inhibition of alpha-CD3 mAb induced IL-2 production in human whole blood
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pyrazolo[3,4-d]pyrimidines containing an extended 3-substituent as potent inhibitors of Lck -- a selectivity insight.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.77 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47787 | — | — | 1 | 8.70 |
| CHEMBL43773 | — | — | 1 | 8.22 |
| CHEMBL295528 | — | — | 1 | 8.10 |
| CHEMBL295601 | — | — | 1 | 7.42 |
| CHEMBL297363 | — | — | 1 | 7.30 |
| CHEMBL46785 | — | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47787 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL43773 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL295528 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL295601 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL297363 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL46785 | — | IC50 | = | 135.0 | nM | 6.87 |