Assay Detail
Binding
CHEMBL841752
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Binding to holo-S100B protein
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification and characterization of small molecule inhibitors of the calcium-dependent S100B-p53 tumor suppressor interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 5.37 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 6.00 |
| CHEMBL185802 | — | — | 1 | 5.70 |
| CHEMBL434915 | — | — | 1 | 5.35 |
| CHEMBL364410 | — | — | 1 | 5.35 |
| CHEMBL365434 | — | — | 1 | 5.09 |
| CHEMBL433966 | — | — | 1 | 4.74 |
| CHEMBL187059 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL185802 | — | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL434915 | — | Kd | = | 4500.0 | nM | 5.35 |
| CHEMBL364410 | — | Kd | = | 4500.0 | nM | 5.35 |
| CHEMBL365434 | — | Kd | = | 8100.0 | nM | 5.09 |
| CHEMBL433966 | — | Kd | = | 18300.0 | nM | 4.74 |
| CHEMBL187059 | — | Kd | = | 120000.0 | nM | - |