Assay Detail
Binding
CHEMBL841753
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Binding affinity towards tubulin
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 5.95 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182319 | TALTOBULIN | 2.0 | 1 | 6.58 |
| CHEMBL188372 | — | — | 1 | 6.16 |
| CHEMBL181650 | — | — | 1 | 6.16 |
| CHEMBL365487 | — | — | 1 | 6.00 |
| CHEMBL364121 | — | — | 1 | 5.92 |
| CHEMBL363127 | — | — | 1 | 5.40 |
| CHEMBL185704 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182319 | TALTOBULIN | Kd | = | 260.0 | nM | 6.58 |
| CHEMBL188372 | — | Kd | = | 700.0 | nM | 6.16 |
| CHEMBL181650 | — | Kd | = | 700.0 | nM | 6.16 |
| CHEMBL365487 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL364121 | — | Kd | = | 1200.0 | nM | 5.92 |
| CHEMBL363127 | — | Kd | = | 4000.0 | nM | 5.40 |
| CHEMBL185704 | — | Kd | = | 4000.0 | nM | 5.40 |