Assay Detail
Binding
CHEMBL841763
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Dissociation constant value against growth factor receptor bound protein 2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Growth factor receptor-bound protein 2 (CHEMBL3663) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Examination of phosphoryl-mimicking functionalities within a macrocyclic Grb2 SH2 domain-binding platform.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 7.86 | 8.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL349373 | — | — | 1 | 8.83 |
| CHEMBL191728 | — | — | 1 | 8.44 |
| CHEMBL424823 | — | — | 1 | 7.79 |
| CHEMBL193015 | — | — | 1 | 7.48 |
| CHEMBL193281 | — | — | 1 | 7.45 |
| CHEMBL263328 | — | — | 1 | 7.17 |
| CHEMBL191718 | — | — | 1 | - |
| CHEMBL363597 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL349373 | — | Kd | = | 1.47 | nM | 8.83 |
| CHEMBL191728 | — | Kd | = | 3.62 | nM | 8.44 |
| CHEMBL424823 | — | Kd | = | 16.2 | nM | 7.79 |
| CHEMBL193015 | — | Kd | = | 33.0 | nM | 7.48 |
| CHEMBL193281 | — | Kd | = | 35.3 | nM | 7.45 |
| CHEMBL263328 | — | Kd | = | 67.0 | nM | 7.17 |
| CHEMBL191718 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL363597 | — | Kd | > | 1000.0 | nM | - |