Assay Detail
Binding
CHEMBL841780
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Inhibitory concentration against recombinant human caspase-3 in neuronal precursor (NT2) cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.58 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179503 | — | — | 1 | 8.85 |
| CHEMBL366927 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179503 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL366927 | — | Ki | = | 5.0 | nM | 8.30 |