Assay Detail
Binding
CHEMBL841902
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transcriptional potency (EC50) at Human estrogen receptor alpha
23
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 7.91 | 10.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 10.74 |
| CHEMBL135739 | — | — | 1 | 10.19 |
| CHEMBL136039 | — | — | 1 | 9.42 |
| CHEMBL335412 | — | — | 1 | 8.57 |
| CHEMBL132868 | — | — | 1 | 8.54 |
| CHEMBL334798 | — | — | 1 | 8.51 |
| CHEMBL134938 | — | — | 1 | 8.28 |
| CHEMBL135695 | — | — | 1 | 8.17 |
| CHEMBL342418 | — | — | 2 | 7.85 |
| CHEMBL135597 | — | — | 1 | 7.80 |
| CHEMBL135649 | — | — | 1 | 7.75 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 7.70 |
| CHEMBL334773 | DIARYLPROPIONITRILE | — | 1 | 7.70 |
| CHEMBL134646 | — | — | 1 | 7.64 |
| CHEMBL132694 | — | — | 1 | 7.40 |
| CHEMBL335620 | — | — | 1 | 7.38 |
| CHEMBL132919 | — | — | 1 | 7.14 |
| CHEMBL334402 | — | — | 1 | 7.02 |
| CHEMBL134892 | — | — | 1 | 6.89 |
| CHEMBL137795 | — | — | 1 | 6.82 |
| CHEMBL2111906 | — | — | 1 | 6.40 |
| CHEMBL133203 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | EC50 | = | 0.018 | nM | 10.74 |
| CHEMBL135739 | — | EC50 | = | 0.064 | nM | 10.19 |
| CHEMBL136039 | — | EC50 | = | 0.38 | nM | 9.42 |
| CHEMBL335412 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL132868 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL334798 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL134938 | — | EC50 | = | 5.2 | nM | 8.28 |
| CHEMBL135695 | — | EC50 | = | 6.7 | nM | 8.17 |
| CHEMBL342418 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL135597 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL135649 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL342418 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL44 | GENISTEIN | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL334773 | DIARYLPROPIONITRILE | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL134646 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL132694 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL335620 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL132919 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL334402 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL134892 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL137795 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2111906 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL133203 | — | EC50 | = | 464.0 | nM | 6.33 |