Assay Detail
Binding
CHEMBL842024
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Inhibitory activity against p56 Lck tyrosine kinase at a concentration of 5 uM ATP.
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.37 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302281 | — | — | 1 | 8.70 |
| CHEMBL68888 | — | — | 1 | 8.40 |
| CHEMBL303195 | — | — | 1 | 8.30 |
| CHEMBL66102 | — | — | 1 | 8.22 |
| CHEMBL67268 | — | — | 1 | 8.10 |
| CHEMBL68430 | — | — | 1 | 7.96 |
| CHEMBL302279 | — | — | 1 | 7.77 |
| CHEMBL305748 | — | — | 1 | 7.70 |
| CHEMBL67598 | — | — | 1 | 7.52 |
| CHEMBL66716 | — | — | 1 | 7.52 |
| CHEMBL71985 | — | — | 1 | 7.40 |
| CHEMBL68773 | — | — | 1 | 6.88 |
| CHEMBL68082 | — | — | 1 | 6.84 |
| CHEMBL69868 | — | — | 1 | 6.58 |
| CHEMBL69544 | — | — | 1 | 6.51 |
| CHEMBL67560 | — | — | 1 | 6.33 |
| CHEMBL67211 | — | — | 1 | 6.03 |
| CHEMBL68663 | — | — | 1 | 5.83 |
| CHEMBL70034 | — | — | 1 | - |
| CHEMBL307982 | — | — | 1 | - |
| CHEMBL69068 | — | — | 1 | - |
| CHEMBL304113 | — | — | 1 | - |
| CHEMBL47940 | — | — | 1 | - |
| CHEMBL71722 | — | — | 1 | - |
| CHEMBL433097 | — | — | 1 | - |
| CHEMBL69649 | — | — | 1 | - |
| CHEMBL302481 | — | — | 1 | - |
| CHEMBL71541 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302281 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL68888 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL303195 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL66102 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL67268 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL68430 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL302279 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL305748 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL67598 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL66716 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL71985 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL68773 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL68082 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL69868 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL69544 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL67560 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL67211 | — | IC50 | = | 942.0 | nM | 6.03 |
| CHEMBL68663 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL70034 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL307982 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL69068 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL304113 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL47940 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL71722 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL433097 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL69649 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL302481 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL71541 | — | IC50 | < | 3.0 | nM | - |