Assay Detail
Functional
CHEMBL842220
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNF-alpha synthesis in human monocytes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Phthalazine PDE4 inhibitors. Part 2: the synthesis and biological evaluation of 6-methoxy-1,4-disubstituted derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.37 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | 2.0 | 1 | 8.89 |
| CHEMBL79902 | — | — | 1 | 8.52 |
| CHEMBL79471 | — | — | 1 | 8.10 |
| CHEMBL79535 | — | — | 1 | 8.05 |
| CHEMBL310387 | — | — | 1 | 7.34 |
| CHEMBL421151 | — | — | 1 | 7.21 |
| CHEMBL81364 | — | — | 1 | 7.14 |
| CHEMBL312375 | — | — | 1 | 7.06 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 6.80 |
| CHEMBL312322 | — | — | 1 | 6.78 |
| CHEMBL70391 | — | — | 1 | 6.65 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.65 |
| CHEMBL80107 | — | — | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL79902 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL79471 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL79535 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL310387 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL421151 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL81364 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL312375 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL312322 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL70391 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL80107 | — | IC50 | = | 273.0 | nM | 6.56 |