Assay Detail
Functional
CHEMBL842236
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibitory activity against leukotriene B4 induced neutrophil chemotaxis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and pharmacological activity of SC-53228, a leukotriene B4 receptor antagonist with high intrinsic potency and selectivity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.48 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422388 | — | — | 1 | 9.96 |
| CHEMBL14823 | SC-41390 | — | 1 | 9.00 |
| CHEMBL167804 | — | — | 1 | 8.89 |
| CHEMBL65061 | LEUKOTRIENE_B4 | — | 1 | 8.75 |
| CHEMBL166699 | — | — | 1 | 8.57 |
| CHEMBL167669 | — | — | 1 | 7.97 |
| CHEMBL167474 | — | — | 1 | 7.89 |
| CHEMBL328492 | — | — | 1 | 7.66 |
| CHEMBL419948 | — | — | 1 | 7.61 |
| CHEMBL355401 | — | — | 1 | - |
| CHEMBL167350 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422388 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL14823 | SC-41390 | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL167804 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL65061 | LEUKOTRIENE_B4 | IC50 | = | 1.79 | nM | 8.75 |
| CHEMBL166699 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL167669 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL167474 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL328492 | — | IC50 | = | 21.9 | nM | 7.66 |
| CHEMBL419948 | — | IC50 | = | 24.4 | nM | 7.61 |
| CHEMBL355401 | — | IC50 | < | 0.16 | nM | - |
| CHEMBL167350 | — | IC50 | < | 0.14 | nM | - |