Assay Detail
Binding
CHEMBL842480
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Binding affinity towards mu opioid receptor using [3H]- -DAMGO (1.5 nM) as radioligand in rat brain membranes
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl3-promoted aminolysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.56 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286053 | — | — | 1 | 6.15 |
| CHEMBL13470 | SNC-80 | — | 1 | 5.32 |
| CHEMBL27432 | — | — | 1 | 5.21 |
| CHEMBL27944 | — | — | 1 | - |
| CHEMBL24035 | — | — | 2 | - |
| CHEMBL28443 | — | — | 1 | - |
| CHEMBL27161 | — | — | 1 | - |
| CHEMBL27779 | — | — | 1 | - |
| CHEMBL416930 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286053 | — | IC50 | = | 702.0 | nM | 6.15 |
| CHEMBL13470 | SNC-80 | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL27432 | — | IC50 | = | 6236.0 | nM | 5.21 |
| CHEMBL27944 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL24035 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL28443 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL27161 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL27779 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL416930 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL24035 | — | IC50 | > | 10000.0 | nM | - |