Assay Detail
Binding
CHEMBL842482
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against mu opioid receptor using guinea pig ileum (GPI) assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A topochemical approach to explain morphiceptin bioactivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.57 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283287 | — | — | 1 | 7.68 |
| CHEMBL267708 | — | — | 1 | 7.54 |
| CHEMBL2371360 | — | — | 1 | 7.51 |
| CHEMBL2371359 | — | — | 1 | 6.96 |
| CHEMBL2371339 | — | — | 1 | 6.77 |
| CHEMBL362991 | MORPHICEPTIN | — | 1 | 6.26 |
| CHEMBL2371340 | — | — | 1 | 6.25 |
| CHEMBL2371336 | — | — | 1 | 5.58 |
| CHEMBL2371361 | — | — | 1 | 4.57 |
| CHEMBL2371337 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283287 | — | IC50 | = | 20.7 | nM | 7.68 |
| CHEMBL267708 | — | IC50 | = | 28.7 | nM | 7.54 |
| CHEMBL2371360 | — | IC50 | = | 30.6 | nM | 7.51 |
| CHEMBL2371359 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL2371339 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL362991 | MORPHICEPTIN | IC50 | = | 552.0 | nM | 6.26 |
| CHEMBL2371340 | — | IC50 | = | 557.0 | nM | 6.25 |
| CHEMBL2371336 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL2371361 | — | IC50 | = | 26900.0 | nM | 4.57 |
| CHEMBL2371337 | — | IC50 | > | 100000.0 | nM | - |