Assay Detail
Binding
CHEMBL842916
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity to neuronal nAChRs was determined by measuring the displacement of [3H]cytisine in rat brain
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor (CHEMBL2094110) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Ligands for brain cholinergic channel receptors: synthesis and in vitro characterization of novel isoxazoles and isothiazoles as bioisosteric replacements for the pyridine ring in nicotine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 7.21 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3 | NICOTINE | 4.0 | 1 | 8.96 |
| CHEMBL268750 | — | — | 1 | 8.38 |
| CHEMBL337777 | — | — | 1 | 8.21 |
| CHEMBL142124 | — | — | 1 | 8.13 |
| CHEMBL10096 | — | — | 1 | 8.13 |
| CHEMBL341937 | — | — | 1 | 8.12 |
| CHEMBL335566 | — | — | 1 | 7.93 |
| CHEMBL138471 | — | — | 1 | 7.85 |
| CHEMBL9732 | R-NICOTINE | — | 1 | 7.80 |
| CHEMBL264213 | — | — | 1 | 7.77 |
| CHEMBL6200 | NORNICOTINE | 1.0 | 1 | 7.66 |
| CHEMBL441291 | — | — | 1 | 7.66 |
| CHEMBL137920 | — | — | 1 | 7.62 |
| CHEMBL138188 | — | — | 1 | 7.46 |
| CHEMBL141310 | — | — | 1 | 7.29 |
| CHEMBL274525 | ABT-418 | — | 1 | 7.28 |
| CHEMBL139012 | — | — | 1 | 7.15 |
| CHEMBL138525 | — | — | 1 | 6.90 |
| CHEMBL139562 | — | — | 1 | 6.68 |
| CHEMBL343496 | — | — | 1 | 6.65 |
| CHEMBL139264 | — | — | 1 | 6.64 |
| CHEMBL274524 | — | — | 1 | 6.48 |
| CHEMBL136337 | — | — | 1 | 6.26 |
| CHEMBL139502 | — | — | 1 | 6.10 |
| CHEMBL140648 | — | — | 1 | 6.05 |
| CHEMBL342644 | — | — | 1 | 5.88 |
| CHEMBL138514 | — | — | 1 | 5.46 |
| CHEMBL423919 | — | — | 1 | 5.30 |
| CHEMBL138673 | — | — | 1 | - |
| CHEMBL136462 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3 | NICOTINE | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL268750 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL337777 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL142124 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL10096 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL341937 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL335566 | — | Ki | = | 11.7 | nM | 7.93 |
| CHEMBL138471 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL9732 | R-NICOTINE | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL264213 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL6200 | NORNICOTINE | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL441291 | — | Ki | = | 21.9 | nM | 7.66 |
| CHEMBL137920 | — | Ki | = | 24.2 | nM | 7.62 |
| CHEMBL138188 | — | Ki | = | 34.3 | nM | 7.46 |
| CHEMBL141310 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL274525 | ABT-418 | Ki | = | 52.9 | nM | 7.28 |
| CHEMBL139012 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL138525 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL139562 | — | Ki | = | 207.0 | nM | 6.68 |
| CHEMBL343496 | — | Ki | = | 222.0 | nM | 6.65 |
| CHEMBL139264 | — | Ki | = | 228.0 | nM | 6.64 |
| CHEMBL274524 | — | Ki | = | 333.0 | nM | 6.48 |
| CHEMBL136337 | — | Ki | = | 552.0 | nM | 6.26 |
| CHEMBL139502 | — | Ki | = | 788.0 | nM | 6.10 |
| CHEMBL140648 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL342644 | — | Ki | = | 1333.0 | nM | 5.88 |
| CHEMBL138514 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL423919 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL138673 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL136462 | — | Ki | > | 10000.0 | nM | - |