Assay Detail
Binding
CHEMBL842992
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]batrachotoxin binding to rat brain neuronal membranes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Sodium channel alpha subunits; brain (Types I, II, III) (CHEMBL2095171) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Batrachotoxin binding site antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.20 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52359 | — | — | 1 | 5.44 |
| CHEMBL55733 | — | — | 1 | 5.35 |
| CHEMBL698 | TETRACAINE | 4.0 | 1 | 5.22 |
| CHEMBL296366 | — | — | 1 | 5.00 |
| CHEMBL298513 | — | — | 1 | 5.00 |
| CHEMBL52258 | — | — | 1 | - |
| CHEMBL55922 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52359 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL55733 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL698 | TETRACAINE | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL296366 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL298513 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL52258 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL55922 | — | IC50 | = | 2000000.0 | nM | - |