Assay Detail
Functional
CHEMBL843258
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Compound was tested for its ability to suppress the release of TNF-alpha (TNF-WBA) in human whole blood after stimulation with LPS.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-alpha production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.84 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24347 | — | — | 1 | 6.02 |
| CHEMBL283429 | — | — | 1 | 5.89 |
| CHEMBL24761 | — | — | 1 | 5.89 |
| CHEMBL283427 | — | — | 1 | 5.85 |
| CHEMBL23725 | — | — | 1 | 5.85 |
| CHEMBL277658 | — | — | 1 | 5.80 |
| CHEMBL542068 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24347 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL283429 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL24761 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL283427 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL23725 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL277658 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL542068 | — | IC50 | = | 2700.0 | nM | 5.57 |