Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL843326

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of v-Src tyrosine kinase autophosphorylation in SR3Y1 cells after 15 hr exposure
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type SR3Y1
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Proto-oncogene tyrosine-protein kinase Src (CHEMBL3014)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis and antitumor activity of novel O-carbamoylmethyloxime derivatives of radicicol.
Ikuina Y, Amishiro N, Miyata M, Narumi H, Ogawa H, Akiyama T, Shiotsu Y, Akinaga S, Murakata C.
J Med Chem (2003) 46 : 2534 -2541
PubMed 12773056 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 7.12 7.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL313587 1 7.85
CHEMBL85730 1 7.77
CHEMBL83069 1 7.60
CHEMBL311607 1 7.37
CHEMBL83305 1 7.27
CHEMBL85011 1 7.25
CHEMBL83070 1 7.17
CHEMBL314705 1 7.16
CHEMBL82750 1 6.85
CHEMBL414883 RADICICOL 1 6.75
CHEMBL313882 1 6.68
CHEMBL84714 1 6.44
CHEMBL315521 1 6.41
CHEMBL84809 1 -
CHEMBL85010 1 -
CHEMBL419849 1 -
CHEMBL85612 1 -
CHEMBL82435 1 -
CHEMBL84564 1 -
CHEMBL84955 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL313587 IC50 = 14.0 nM 7.85
CHEMBL85730 IC50 = 17.0 nM 7.77
CHEMBL83069 IC50 = 25.0 nM 7.60
CHEMBL311607 IC50 = 43.0 nM 7.37
CHEMBL83305 IC50 = 54.0 nM 7.27
CHEMBL85011 IC50 = 56.0 nM 7.25
CHEMBL83070 IC50 = 67.0 nM 7.17
CHEMBL314705 IC50 = 70.0 nM 7.16
CHEMBL82750 IC50 = 140.0 nM 6.85
CHEMBL414883 RADICICOL IC50 = 180.0 nM 6.75
CHEMBL313882 IC50 = 210.0 nM 6.68
CHEMBL84714 IC50 = 360.0 nM 6.44
CHEMBL315521 IC50 = 390.0 nM 6.41
CHEMBL84809 IC50 > 1000.0 nM -
CHEMBL85010 IC50 > 1000.0 nM -
CHEMBL419849 IC50 > 1000.0 nM -
CHEMBL85612 IC50 < 10.0 nM -
CHEMBL82435 IC50 > 1000.0 nM -
CHEMBL84564 IC50 > 1000.0 nM -
CHEMBL84955 IC50 > 1000.0 nM -