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Assay Detail

CHEMBL843812

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity against bovine brain nNOS (neuronal).
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Tissue Brain
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Nitric oxide synthase 1 (CHEMBL3568)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and evaluation of peptidomimetics as selective inhibitors and active site probes of nitric oxide synthases.
Huang H, Martásek P, Roman LJ, Silverman RB.
J Med Chem (2000) 43 : 2938 -2945
PubMed 10956202 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 5.47 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL44833 1 6.89
CHEMBL1202106 1 6.48
CHEMBL91256 1 6.46
CHEMBL88107 1 6.35
CHEMBL92493 1 6.34
CHEMBL88267 1 6.27
CHEMBL317521 1 6.24
CHEMBL101766 1 5.62
CHEMBL101042 1 5.34
CHEMBL100761 1 5.14
CHEMBL317303 1 4.99
CHEMBL98086 1 4.72
CHEMBL420637 1 4.55
CHEMBL100524 1 4.52
CHEMBL101214 1 4.51
CHEMBL318654 1 4.33
CHEMBL98383 1 4.28

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL44833 Ki = 130.0 nM 6.89
CHEMBL1202106 Ki = 330.0 nM 6.48
CHEMBL91256 Ki = 350.0 nM 6.46
CHEMBL88107 Ki = 450.0 nM 6.35
CHEMBL92493 Ki = 460.0 nM 6.34
CHEMBL88267 Ki = 540.0 nM 6.27
CHEMBL317521 Ki = 580.0 nM 6.24
CHEMBL101766 Ki = 2400.0 nM 5.62
CHEMBL101042 Ki = 4600.0 nM 5.34
CHEMBL100761 Ki = 7300.0 nM 5.14
CHEMBL317303 Ki = 10200.0 nM 4.99
CHEMBL98086 Ki = 19000.0 nM 4.72
CHEMBL420637 Ki = 28400.0 nM 4.55
CHEMBL100524 Ki = 30400.0 nM 4.52
CHEMBL101214 Ki = 30600.0 nM 4.51
CHEMBL318654 Ki = 47000.0 nM 4.33
CHEMBL98383 Ki = 52000.0 nM 4.28