Assay Detail
Functional
CHEMBL844073
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against progesterone receptor (PR) in an alkaline phosphatase assay in the T47D human breast carcinoma cell line
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | T47D |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
6-Aryl-1,4-dihydro-benzo[d][1,3]oxazin- 2-ones: a novel class of potent, selective, and orally active nonsteroidal progesterone receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.83 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 9.89 |
| CHEMBL138059 | — | — | 1 | 8.10 |
| CHEMBL138005 | — | — | 1 | 8.09 |
| CHEMBL136721 | — | — | 1 | 7.82 |
| CHEMBL303209 | — | — | 1 | 7.77 |
| CHEMBL136166 | — | — | 1 | 7.71 |
| CHEMBL343306 | — | — | 1 | 7.64 |
| CHEMBL139406 | — | — | 1 | 7.58 |
| CHEMBL136806 | — | — | 1 | 7.52 |
| CHEMBL342199 | — | — | 1 | 7.52 |
| CHEMBL343083 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL138059 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL138005 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL136721 | — | IC50 | = | 15.1 | nM | 7.82 |
| CHEMBL303209 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL136166 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL343306 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL139406 | — | IC50 | = | 26.2 | nM | 7.58 |
| CHEMBL136806 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL342199 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL343083 | — | IC50 | = | 300.0 | nM | 6.52 |